Gastric Cancer Risk Prediction Using an Epidemiological Risk Assessment Model and Polygenic Risk Score

PRSice: Polygenic Risk Score software

SUMMARY A polygenic risk score (PRS) is a sum of trait-associated alleles across many genetic loci, typically weighted by effect sizes estimated from a genome-wide association study. The application of PRS has grown in recent years as their utility for detecting shared genetic aetiology among traits has become appreciated; PRS can also be used to establish the presence of a genetic signal in un...

Schizophrenia polygenic risk score and psychotic risk detection.

Korean Risk Assessment Model for Breast Cancer Risk Prediction

PURPOSE We evaluated the performance of the Gail model for a Korean population and developed a Korean breast cancer risk assessment tool (KoBCRAT) based upon equations developed for the Gail model for predicting breast cancer risk. METHODS Using 3,789 sets of cases and controls, risk factors for breast cancer among Koreans were identified. Individual probabilities were projected using Gail's ...

Relationship between diet diversity score and breast cancer risk

Background: The average age of women with breast cancer in Iran is at least 10 years lower in comparison to developed countries and the incidence of the disease in Iranian women is on a rise. According to studies, diets that are diverse in food groups can play a role in protecting against chronic diseases including cardiovascular diseases and cancer. Diet diversity score is an indicator used to...

Breast cancer risk assessment in Iranian women by Gail model

  Abstract   Background: Due to the high incidence of breast cancer and the effect of its early   diagnosis on decreasing morbidity and mortality, we used the Gail model to study   breast cancer risk in Iranian women.   Methods: This study was done in a simple randomized way. Participants were 2000   Iranian women older than 35 years old. The questionnaire consisted of demographic   data such a...